• Michael Pigula, Zhiming Mai, Sriram Anbil, Myung-Gyu Choi, Kenneth Wang, Edward Maytin, Brian Pogue and Tayyaba Hasan. Dramatic Reduction of Distant Pancreatic Metastases Using Local Light Activation of Verteporfin with Nab-Paclitaxel. Cancers. 2021; 13(22):5781.
  • Dual Function Antibody Conjugates for Multimodal Imaging and Photoimmunotherapy of Cancer Cell. Mohammad A Saad, Marvin Xavierselvan, Hamza A Sharif, Scott Selfridge, Robert Pawle, Mark Varvares, Srivalleesha Mallidi, Tayyaba Hasan. Photochem Photobiol. 2021;10.1111/php.13501. Dual Function Antibody Conjugates for Multimodal Imaging and Photoimmunotherapy of Cancer Cell. Photochem Photobiol. 2021;10.1111/php.13501.


  • Ryan T. Lang and Bryan Q. Spring, Two-photon peak molecular brightness spectra reveal long-wavelength enhancements of multiplexed imaging depth and photostability,” Biomed. Opt. Express, 2021:12 (9), 5909-5919. https://doi.org/10.1364/BOE.433989.
  • *Yuri Hanada, Stephen P Pereira, Brian Pogue, Edward V Maytin, Tayyaba Hasan, Bryan Linn, Tiffany Mangels-Dick, Kenneth K Wang. EUS-guided verteporfin photodynamic therapy for pancreatic cancer. Gastrointest Endosc. 2021;94(1):179-186. doi:10.1016/j.gie.2021.02.027
  • *Phuong Vincent, Matthew E Maeder, Brady Hunt, Bryan Linn, Tiffany Mangels-Dick, Tayyaba Hasan, Kenneth K Wang and Brian W Pogue. CT radiomic features of photodynamic priming in clinical pancreatic adenocarcinoma treatment. Phys Med Biol. 2021:66(17): 175006. doi: 10.1088/1361-6560/ac1458. Online ahead of print.  PMID: 34261044.
  • Ryan T. Lang, Mohammad A Saad, Akilian Palanisami, Eric M. Kercher, L Price, Bryan Q Spring. Micro-image mosaicking of video-rate multiplexed microendoscopy enables analysis of tumor heterogeneity. J Biomed Opt. (Submitted).
  • *Pushpamali De Silva, Shazia Bano, Brian W. Pogue, Kenneth K. Wang, Edward V. Maytin and Tayyaba Hasan. Photodynamic priming with triple-receptor targeted nanoconjugates that trigger T cell-mediated immune responses in a 3D in vitro heterocellular model of pancreatic cancer. Nanophotonics, Prepublished online, 2021, pp. 000010151520210304. https://doi.org/10.1515/nanoph-2021-0304
  • Mina Guirguis, Chanda Bhandari, Junjie Li, Menitte Eroy, Sushant Prajapati, Ryan Margolis, Navadeep Shrivastava, Kenneth Hoyt, Tayyaba Hasanand Girgis Obaid. Membrane composition is a functional determinant of NIR-activable liposomes in orthotopic head and neck cancer” Nanophotonics, 2021:20210191. https://doi.org/10.1515/nanoph-2021-0191.
  • Brady Hunt, Alberto Ruiz, Brian Pogue. Smartphone-based imaging systems for medical applications: a critical review. J Biomed Opt. 2021;26(4):040902. doi:10.1117/1.JBO.26.4.040902
  • Chanda Bhandari, Mina Guirguis, N Anna Savan, Navadeep Shrivastava, Sabrina Oliveira, Tayyaba Hasan, Girgis Obaid. What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity. Nano Today. 2021 Feb;36:101052. doi: 10.1016/j.nantod.2020.101052.
  • *Phuong Vincent, Petr Bruza, Scott M Palisoul, Jason R Gunn, Kimberley S Samkoe, P Jack Hoopes, Tayyaba Hasan, Brian W Pogue. Visualization and quantification of pancreatic tumor stroma in fresh tissue via ultraviolet surface excitation. J Biomed Opt. 2021;26(1):016002. doi:10.1117/1.JBO.26.1.016002
  • *Girgis Obaid, Kimberley Samkoe, Kenneth Tichauer, Shazia Bano, Yeonjae Park, Zachary Silber, Sassan Hodge, Susan Callaghan, Mina Guirguis, Srivalleesha Mallidi, Brian Pogue, Tayyaba Hasan. Is Tumor Cell Specificity Distinct from Tumor Selectivity In Vivo?: A Quantitative NIR Molecular Imaging Analysis of Nanoliposome Targeting. Nano Res. 2021;14(5):1344-1354. doi:10.1007/s12274-020-3178-x
  • *Sanjay Anand, Timothy A. Chan, Tayyaba Hasan, and Edward V. Maytin. Current Prospects for Treatment of Solid Tumors via Photodynamic, Photothermal, or Ionizing Radiation Therapies Combined with Immune Checkpoint Inhibition (A Review). Pharmaceuticals (Basel). 2021;14(5):447. doi:10.3390/ph14050447


  • *Phuong Vincent, Hexuan Wang, Michael Nieskoski, Jason R Gunn, Kalya Marra, P Jack Hoopes, Kimberley S Samkoe, Marvin M Doyley, Tayyaba Hasan, Brian W Pogue. High-Resolution Ex Vivo Elastography to Characterize Tumor Stromal Heterogeneity In Situ in Pancreatic Adenocarcinoma. IEEE Trans Biomed Eng. 2020 Sep;67(9):2490-2496. doi: 10.1109/TBME.2019.2963562. PMID: 31902753; PMCID: PMC7494001.
  • Marek Scholz, Xu Cao, Jason R. Gunn, Petr Brůža, and Brian Pogue. pO2-weighted imaging in vivo by delayed fluorescence of intracellular Protoporphyrin IX. Opt. Lett. 2020; 45, 284-287. Doi: https://doi.org/10.1364/OL.45.000284
  • *Shazia Bano, Girgis Obaid, Joseph W. R. Swain, Marina Yamada, Brian W. Pogue, Kenneth Wang, Tayyaba Hasan. NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer. J Clin Med. 2020 Aug; 9(8): 2390.  Published online 2020 Jul 27. doi: 10.3390/jcm9082390. PMCID: PMC7464411
  • Mans Broekgaarden, Ahmed Alkhateeb, Shazia Bano, Anne-Laure Bulin, Girgis Obaid, Imran Rizvi, and Tayyaba Hasan. Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. Cancers (Basel). 2020 May 29;12(6):1401. doi: 10.3390/cancers12061401. PMID: 32485915; PMCID: PMC7352584.
  • Marek Scholz, Arthur F. Petusseau, Jason R. Gunn, M. Shane Chapman, Brian W. Pogue. Imaging of hypoxia, oxygen consumption and recovery in vivo during ALA-photodynamic therapy using delayed fluorescence of Protoporphyrin IX. Photodiagnosis Photodyn Ther. 2020 Jun; 30:101790. doi: 10.1016/j.pdpdt.2020.101790. Epub 2020 Apr 26. PMID: 32344195
  • Mans Broekgaarden, Ahmed Alkhateeb, Shazia Bano, Anne-Laure Bulin, Girgis Obaid, Imran Rizvi, Tayyaba Hasan. Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. Cancers (Basel) 2020 Jun; 12(6): 1401.  Published online 2020 May 29. doi: 10.3390/cancers12061401 PMCID: PMC7352584
  • Liberty N Gendron, Dillon C Zites, Ethan P M LaRochelle, Jason R Gunn, Brian W Pogue, Thomas A Shell, Jennifer R Shell. Tumor targeting vitamin B12 derivatives for X-ray induced treatment of pancreatic adenocarcinoma. Photodiagnosis Photodyn Ther. 2020 Jun ;30:101637. doi: 10.1016/j.pdpdt.2019.101637. Epub 2019 Dec 31. PMID: 31899377.
  • *Sriram Anbil, Michael Pigula, Huang-Chiao Huang, Srivalleesha Mallidi, Mans Broekgaarden, Yan Baglo, Pushpamali De Silva, Diane M Simeone, Mari Mino-Kenudson, Edward V Maytin, Imran Rizvi, Tayyaba Hasan. Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy. Mol Cancer Ther. 2020 Jun;19(6):1308-1319. doi: 10.1158/1535-7163.MCT-19-0791.
  • Amissi Sadiki, Eric M. Kercher, Haibin Lu, Ryan T. Lang, Bryan Q. Spring, Zhaohui Sunny Zhou. Site-specific Bioconjugation and Convergent Click Chemistry Enhances Antibody-Chromophore Conjugate Binding Efficiency. Photochem Photobiol. 2020;96(3):596-603. doi:10.1111/php.13231
  • Tobias J Moritz, Youbo Zhao, Michael F Hinds, Jason R Gunn, Jennifer R Shell, Brian W Pogue, Steven J Davis. Multispectral singlet oxygen and photosensitizer luminescence dosimeter for continuous photodynamic therapy dose assessment during treatment. J Biomed Opt. 2020 Mar;25(6):1-13. doi: 10.1117/1.JBO.25.6.063810.
  • Marek Scholz, Jason R. Gunn, Geoffrey P. Luke, Brian W. Pogue. Imaging of singlet oxygen feedback delayed fluorescence and lysosome permeabilization in tumor in vivo during photodynamic therapy with aluminum phthalocyanine. J Biomed Opt. 2020 Jun; 25(6): 063806.  Published online 2020 Jan 9. doi: 10.1117/1.JBO.25.6.063806. PMCID: PMC6951482
  • Tomonori Yano, Kenneth K. Wang. Photodynamic Therapy for Gastrointestinal Cancer (Special Issue dedicated to Dr. Thomas Dougherty). Photochem Photobiol, 2020; 96: 517-523. doi:10.1111/php.13206.
  • *Edward V Maytin, Tayyaba Hasan. Vitamin D and Other Differentiation-promoting Agents as Neoadjuvants for Photodynamic Therapy of Cancer. Photochemistry and Photobiology. 2020 May; 96(3):529-538. DOI: 10.1111/php.13230.
  • *Ethan P M LaRochelle, Michael Shane Chapman, Edward V Maytin, Tayyaba Hasan, Brian W Pogue. Weather-informed Light-tissue Model-Based Dose Planning for Indoor Daylight Photodynamic Therapy. Photochem Photobiol. 2020;96(2):320-326. doi:10.1111/php.13170.
  • Pushpamali De Silva, Mohammad A. Saad, Hanna C. Thomsen, Shazia Bano, Shoaib Ashraf and Tayyaba Hasan. Photodynamic therapy, priming and optical imaging: potential co-conspirators in treatment design and optimization. Journal of Porphyrins and Phthalocyanines,2020; 24(11):1320-1360.doi: https://doi.org/10.1142/S1088424620300098.
  • *Alberto J. Ruiz, Ethan Phillip M. LaRochelle, Jason R. Gunn, Sally M. Hull, Tayyaba Hasan, M. Shane Chapman, Brian W. Pogue. Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-IX-based photodynamic therapy in skin. J Biomed Opt. 2020 Jun; 25(6): 063802.  Published online 2019 Dec 9. doi: 10.1117/1.JBO.25.6.063802. PMCID: PMC6901011.


  • Shubhankar Nath, Mohammad Ahsan Saad, Michael Pigula, Joseph W.R. Swain, Tayyaba Hasan. Photoimmunotherapy of Ovarian Cancer: A Unique Niche in the Management of Advanced Disease. Cancers (Basel) 2019 Dec; 11(12): 1887.  Published online 2019 Nov 27. doi: 10.3390/cancers11121887. PMCID: PMC6966499
  • Jingjing Lu, Bhaskar Roy, Marlys Anderson, Cadman L. Leggett, Michael J. Levy, Brian Pogue, Tayyaba Hasan, Kenneth K. Wang. Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment. J Biomed Opt. 2019 Nov; 24(11):118001. doi: 10.1117/1.JBO.24.11.118001. PMCID: PMC7003148
  • Goran Hamid Mohammad, Vessela Vassileva, Pilar Acedo, Steven W. M. Olde Damink, Massimo Malago, Dipok Kumar Dhar, Stephen P. Pereira. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) 2019 Sep; 11(9): 1372.  Published online 2019 Sep 16. doi: 10.3390/cancers11091372. PMCID: PMC6770573
  • Mans Broekgaarden, Anne-Laure Bulin, Jane Frederick, Zhiming Mai, Tayyaba Hasan. Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes. J Clin Med. 2019 Sep; 8(9): 1399.  Published online 2019 Sep 6. doi: 10.3390/jcm8091399. PMCID: PMC6788194
  • Kercher EM, Nath S, Rizvi I, Spring BQ. Cancer cell-targeted and activatable photoimmunotherapy spares T Cells in a 3D co-culture model. Photochem Photobiol. 2019 Aug 19;96(2):295-300. PubMed PMID: 31424560; PubMed Central PMCID: PMC7028482.
  • Anne-Laure Bulin, Mans Broekgaarden, Diane Simeone, Tayyaba Hasan.  Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids. Oncotarget. 2019 Apr 5; 10(27): 2625–2643. Published online 2019 Apr 5. doi: 10.18632/oncotarget.26780. PMCID: PMC6499000
  • Ethan P M LaRochelle, Kayla Marra, Robert E LeBlanc, M Shane Chapman, Edward V Maytin, Brian W Pogue. Modeling PpIX effective light fluence at depths into the skin for PDT dose comparison. Photodiagnosis Photodyn Ther. 2019 Mar;25:425-435. doi: 10.1016/j.pdpdt.2019.01.022. Epub 2019 Jan 25. PMID: 30685548.
  • Davoudzadeh N, Ducourthial G, Spring BQ. Custom fabrication and mode-locked operation of a femtosecond fiber laser for multiphoton microscopy. Sci Rep. 2019 Mar 12;9(1):4233. PubMed PMID: 30862800; PubMed Central PMCID: PMC6414530.
  • Sanjay Anand, Anton Yasinchak, Taylor Bullock, Mukul Govande, Edward V. Maytin. A non-toxic approach for treatment of breast cancer and its metastases: capecitabine enhanced photodynamic therapy in a murine breast tumor model. J Cancer Metastasis Treat. Author manuscript; available in PMC 2019 Feb 8. Published in final edited form as: J Cancer Metastasis Treat. 2019; 5: 6. Published online 2019 Jan 24.doi: 10.20517/2394-4722.2018.98. PMCID: PMC636808
  • Imran Rizvi, Shubhankar Nath, Girgis Obaid, Mustafa Kemal Ruhi, Kaitlin Moore, Shazia Bano, David Kessel, Tayyaba Hasan. A Combination of Visudyne and a Lipid-Anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Photochem Photobiol. 2019 Jan; 95(1): 419–429. Published online 2019 Jan 7.  doi: 10.1111/php.13066 PMCID: PMC7473467


  • Hexuan Wang, Reem Mislati, Rifat Ahmed, Phuong Vincent, Solumtochukwu Nwabunwanne, Jason R. Gunn, Brian W. Pogue, Marvin M. Doyley. Elastography can map the local inverse relationship between shear modulus and drug delivery within the pancreatic ductal adenocarcinoma microenvironment. Clin Cancer Res. 2019 Apr 1; 25(7): 2136–2143. Published online 2018 Oct 23.  doi: 10.1158/1078-0432.CCR-18-2684. PMCID: PMC6445768
  • Michael Pigula, Huang-Chiao Huang, Srivalleesha Mallidi, Sriram Anbil, Joyce Liu, Zhiming Mai, Tayyaba Hasan. Size-dependent Tumor Response to Photodynamic Therapy and Irinotecan Monotherapies Revealed by Longitudinal Ultrasound Monitoring in an Orthotopic Pancreatic Cancer Model. Photochem Photobiol. 2019 Jan; 95(1): 378–386. Published online 2018 Oct 17.  doi: 10.1111/php.13016. PMCID: PMC6905616
  • Girgis Obaid, Wendong Jin, Shazia Bano, David Kessel, Tayyaba Hasan. Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells. Photochem Photobiol. 2019 Jan; 95(1): 364–377. Published online 2018 Oct 13.  doi: 10.1111/php.13002. PMCID: PMC6347486
  • Brian W. Pogue, Brian C Wilson. Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine. J Biomed Opt. 2018 Oct;23(12):1-17. DOI: 10.1117/1.JBO.23.12.121610, PMCID: PMC6197862
  • Kayla Marra, Ethan P. LaRochelle, M. Shane Chapman, P. Jack Hoopes, Karina Lukovits, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue. Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo. Photochem Photobiol. 2018 Sep; 94(5): 1049–1057. Published online 2018 May 16.  doi: 10.1111/php.12923. PMCID: PMC6135665
  • Huang-Chiao Huang, Michael Pigula, Yanyan Fang, Tayyaba Hasan. Immobilization of Photoimmunoconjugates on Nanoparticles Leads to Enhanced Light-activated Biological Effects. Small. 2018 Jul 1: e1800236. Published online 2018 Jul 1.  doi: 10.1002/smll.201800236. PMCID: PMC6312758
  • Edward V. Maytin, Urvashi Kaw, Muneeb Ilyas, Judith A. Mack, Bo Hu. Blue light versus red light for photodynamic therapy of basal cell carcinoma in patients with Gorlin syndrome: A bilaterally controlled comparison study. Photodiagnosis Photodyn Ther. Photodiagnosis Photodyn Ther. 2018 Jun; 22: 7-13. Published online 2018 Feb 19. doi:10.1016/j.pdpdt.2018.02.009. PMCID: PMC5985214
  • Imran Rizvi, Girgis Obaid, Shazia Bano, Tayyaba Hasan, David Kessel. Photodynamic Therapy: Promoting In Vitro Efficacy of Photodynamic Therapy by Liposomal Formulations of a Photosensitizing Agent. Lasers Surg Med. 2018 Jul; 50(5): 499–505. Published online 2018 Mar 11.  doi: 10.1002/lsm.22813. PMCID: PMC7449601
  • Mans Broekgaarden, Imran Rizvi, Anne-Laure Bulin, Ljubica Petrovic, Ruth Goldschmidt, Iqbal Massodi, Jonathan P. Celli, Tayyaba Hasan. Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget. 2018 Feb 27; 9(16): 13009–13022.  Published online 2018 Feb 6. doi: 10.18632/oncotarget.24425. PMCID: PMC5849191


  • Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, Jason Gunn, Scott C. Davis, Kimberley S. Samkoe, M. Shane Chapman, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue. Assessing daylight & low-light photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ. Photodiagnosis Photodyn Ther. Author manuscript; available in PMC 2017 Dec 7.Photodiagnosis Photodyn Ther. 2017 Dec; 20: 227-233. Published online 2017 Oct 14. doi:10.1016/j.pdpdt.2017.10.005. PMCID: PMC5718943
  • Anne-Laure Bulin, Mans Broekgaarden, Tayyaba Hasan. Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids. Sci Rep. 2017; 7: 16645.  Published online 2017 Nov 30. doi: 10.1038/s41598-017-16622-9. PMCID: PMC5709388
  • Huang-Chiao Huang, Imran Rizvi, Joyce Liu, Sriram Anbil, Ashish Kalra, Helen Lee, Yan Baglo, Nancy Paz, Douglas Hayden, Steve Pereira, Brian W. Pogue, Jonathan Fitzgerald, Tayyaba Hasan. Photodynamic priming mitigates chemotherapeutic selection pressures and improves drug delivery. Cancer Res. 2018 Jan 15; 78(2): 558–571. Published online 2017 Nov 29.  doi: 10.1158/0008-5472.CAN-17-1700. PMCID: PMC5771811
  • Huang-Chiao Huang, Joyce Liu, Yang Baglo, Imran Rizvi, Sriram Anbil, Michael Pigula, Tayyaba Hasan. Mechanism informed repurposing of minocycline overcomes resistance to topoisomerase inhibition for peritoneal carcinomatosis. Mol Cancer Ther. 2018 Feb; 17(2): 508–520. Published online 2017 Nov 22.  doi: 10.1158/1535-7163.MCT-17-0568. PMCID: PMC5805648
  • Hexuan Wang, Michael D. Nieskoski, Kayla Marra, Jason R. Gunn, Stuart B. Trembly, Brian W. Pogue, Marvin M. Doyley. Elastographic assessment of xenograft pancreatic tumors. Ultrasound Med Biol. 2017 Dec; 43(12): 2891–2903. Published online 2017 Sep 28.  doi: 10.1016/j.ultrasmedbio. 2017.08.008. PMCID: PMC569371
  • Michael D. Nieskoski, Kayla Marra, Jason R. Gunn, P. Jack Hoopes, Marvin M. Doyley, Tayyaba Hasan, B. Stuart Trembly, Brian W. Pogue. Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer. Sci Rep. 2017; 7: 10093.  Published online 2017 Aug 30. doi: 10.1038/s41598-017-10671-w. PMCID: PMC5577321
  • Girgis Obaid, Bryan Q. Spring, Shazia Bano, Tayyaba Hasan. Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery. J Biomed Opt. 2017 Dec; 22(12): 121607.  Published online 2017 Aug 29. doi: 10.1117/1.JBO.22.12.121607. PMCID: PMC5574035
  • Noor-L-Houda Bekkali, Tom Thomas, Margaret Geraldine Keane, Sam Murray, Deepak Joshi, Ghassan Elsayed, Gavin James Johnson, Michael Huw Chapman, Stephen Paul Pereira, George John Mitchell Webster. Preventing Post-ERCP Pancreatitis: The Role of Prophylactic Pancreatic Duct Stenting in the Rectal NSAID Era. JOP. 2017 Jul; 18(4): 316-319. Published online 2017 Jul 31. PMCID: PMC5933872
  • Y Chen, SA Xue, S Behboudi, GH Mohammad, SP Pereira, EC Morris. Ex vivo PD-L1/PD-1 pathway blockade reverses dysfunction of circulating CEA specific T cells in pancreatic cancer patients. Clin Cancer Res. Author manuscript; available in PMC 2017 Nov 13. Clin Cancer Res. 2017 Oct 15; 23(20): 6178‚Äì6189. Published online 2017 Jul 14. doi:10.1158/1078-0432.CCR-17-1185. PMCID: PMC5683391
  • Michael D. Nieskoski, Kayla Marra, Jason R. Gunn, Stephen C. Kanick, Marvin M. Doyley, Tayyaba Hasan, Stephen P. Pereira, B. Stuart Trembly, Brian W. Pogue. Separation of Solid Stress From Interstitial Fluid Pressure in Pancreas Cancer Correlates With Collagen Area Fraction. J Biomech Eng. 2017 Jun; 139(6): 0610021–0610028.  Published online 2017 Apr 18. doi: 10.1115/1.4036392. PMCID: PMC6993781
  • Brian W. Pogue, Kenneth K. Wang. Cancer diagnostics: Light scattering by pancreatic cysts. Nat Biomed Eng 1, 0060 (2017). https://doi.org/10.1038/s41551-017-0060
  • Sanjay Anand, Kishore R. Rollakanti, Nikoleta Brankov, Douglas E. Brash, Tayyaba Hasan, Edward V. Maytin. Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53 -independent mechanism that increases protoporphyrin IX levels and tumor cell death. Mol Cancer Ther. 2017 Jun; 16(6): 1092–1101. Published online 2017 Mar 23.  doi: 10.1158/1535-7163.MCT-16-0608. PMCID: PMC5497500
  • Margaret G Keane, Matthew T Huggett, Michael H Chapman, Gavin J Johnson, George J Webster, Douglas Thorburn, James Mackay, Stephen P Pereira. Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology. Br J Cancer. 2017 Jan 31; 116(3): 349-355. Published online 2017 Jan 12. Doi:10.1038/bjc.2016.447. PMCID: PMC5294492
  • Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan. Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? Korean J Intern Med. 2017 Jan; 32(1): 1–10.  Published online 2017 Jan 1. doi: 10.3904/kjim.2016.200. PMCID: PMC5214731


  • Ana Luiza Ribeiro de Souza, Kayla Marra, Jason Gunn, Kimberley S Samkoe, Stephen Chad Kanick, Scott C Davis, M Shane Chapman, Edward V Maytin, Tayyaba Hasan, Brian W Pogue. Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer. Br J Cancer. 2016 Sep 27; 115(7): 805–813.  Published online 2016 Aug 30. doi: 10.1038/bjc.2016.267. PMCID: PMC5046214
  • Girgis Obaid, Mans Broekgaarden, Anne-Laure Bulin, Huang-Chiao Huang, Jerrin Kuriakose, Joyce Liu, Tayyaba Hasan. Photonanomedicine: A Convergence of Photodynamic Therapy and Nanotechnology. Nanoscale. Author manuscript; available in PMC 2017 Jul 7. Published in final edited form as: Nanoscale. 2016 Jul 7; 8(25): 12471–12503. Published online 2016 Jun 20.  doi: 10.1039/c5nr08691d. PMCID: PMC4956486
  • Brian W. Pogue, Keith D. Paulsen, Kimberley S. Samkoe, Jonathan T. Elliott, Tayyaba Hasan, Theresa V. Strong, Daniel R. Draney, Joachim Feldwisch. Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention. Med Phys. 2016 Jun; 43(6): 3143–3156.  Published online 2016 May 31. doi: 10.1118/1.4951732. PMCID: PMC4902810
  • A photoactivable multi-inhibitor nanoliposome for tumour contr ol and simultaneous inhibition of treatment escape pathways. Bryan Q. Spring, R. Bryan Sears, Lei Zak Zheng, Zhiming Mai, Reika Watanabe, Margaret E. Sherwood, David A. Schoenfeld, Brian W. Pogue, Stephen P. Pereira, Elizabeth Villa, Tayyaba Hasan. Nat Nanotechnol. 2016 Apr; 11(4): 378–387. Published online 2016 Jan 18. doi: 10.1038/nnano.2015.311. PMCID: PMC4821671
  • Matthew T. Huggett, Slavica Tudzarova, Ian Proctor, Marco Loddo, Margaret G. Keane, Kai Stoeber, Gareth H. Williams, Stephen P. Pereira. Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint. Oncotarget. 2016 Apr 5; 7(14): 18495-18507.  Published online 2016 Feb 23.doi:10.18632/oncotarget.7611. PMCID: PMC4951304
  • Goran Hamid Mohammad, S. W. M. Olde Damink, Massimo Malago, Dipok Kumar Dhar, Stephen P. Pereira. Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome. PLoS One. 2016; 11(3): e0151635.  Published online 2016 Mar 18. doi:10.1371/journal.pone.0151635. PMCID: PMC4798246
  • Brian W Pogue, Jonathan T Elliott, Stephen C Kanick, Scott C Davis, Kimberley S Samkoe, Edward V Maytin, Stephen P Pereira, Tayyaba Hasan. Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success. Phys Med Biol. 2016; 61(7): R57-R89. doi:10.1088/0031-9155/61/7/R57


  • Huang-Chiao Huang, Srivalleesha Mallidi, Joyce Liu, Chun-Te Chiang, Zhiming Mai, Ruth Goldschmidt, Neema Ebrahim-Zadeh, Imran Rizvi, Tayyaba Hasan. Photodynamic therapy synergizes with irinotecan to overcome compensatory mechanisms and improve treatment outcomes in pancreatic cancer. Cancer Res. Author manuscript; available in PMC 2017 Mar 1. Published in final edited form as: Cancer Res. 2016 Mar 1; 76(5): 1066–1077. Published online 2015 Dec 30.  doi: 10.1158/0008-5472.CAN-15-0391. PMCID: PMC4775276
  • Shifalika Tangutoori, Bryan Q. Spring, Zhiming Mai, Akilan Palanisami, Lawrence Mensah, Tayyaba Hasan. Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic cancer. Nanomedicine. 2016 Jan; 12(1): 223–234. doi: 10.1016/j.nano.2015.08.007. PMCID: PMC4728029
  • SC Kanick, SC Davis, Y Zhao, KL Sheehan, T Hasan, EV Maytin, BW Pogue, MS Chapman. Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. Photodiagnosis Photodyn Ther. 2015 Dec; 12(4): 561-566. Published online 2015 Oct 22.  doi:10.1016/j.pdpdt.2015.10.006. MCID: PMC4684466
  • Kishore R. Rollakanti, Sanjay Anand, Scott C. Davis, Brian W. Pogue, Edward V. Maytin. Noninvasive Optical Imaging of UV-Induced Squamous Cell Carcinoma in Murine Skin: Studies of Early Tumor Development and Vitamin D Enhancement of Protoporphyrin IX Production. Photochem Photobiol. 2015 Nov; 91(6): 1469–1478. Published online 2015 Sep 25.  doi: 10.1111/php.12503. PMCID: PMC4631687
  • Kishore R. Rollakanti, Sanjay Anand, Scott C. Davis, Brian W. Pogue, Edward V. Maytin. Noninvasive Optical Imaging of UV-Induced Squamous Cell Carcinoma in Murine Skin: Studies of Early Tumor Development and Vitamin D Enhancement of Protoporphyrin IX Production. Photochem Photobiol. 2015 Nov; 91(6): 1469–1478. Published online 2015 Sep 25.  doi: 10.1111/php.12503. PMCID: PMC4631687
  • Toshihiro Kushibiki, Yupeng Tu, Adnan O. Abu-Yousif, Tayyaba Hasan. Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation. Sci Rep. 2015; 5: 13114.  Published online 2015 Aug 17. doi: 10.1038/srep13114. PMCID: PMC4538568
  • Tomasz P Radon, Nathalie J Massat, Richard Jones, Wasfi Alrawashdeh, Laurent Dumartin, Darren Ennis, Stephen W Duffy, Hemant M Kocher, Stephen P Pereira, Luisa Guarner, Cristiane M Nascimento, Francisco X Real, Nuria Malats, John Neoptolemos, Eithne Costello, William Greenhalf, Nick R Lemoine, Tatjana Crnogorac-Jurcevic. Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma. Clin Cancer Res. Clin Cancer Res. 2015 Aug 1; 21(15): 3512-3521.doi:10.1158/1078-0432.CCR-14-2467. PMCID: PMC4539580
  • Martina D’Aronzo, Manlio Vinciguerra, Tommaso Mazza, Concetta Panebianco, Chiara Saracino, Stephen P. Pereira, Paolo Graziano, Valerio Pazienza. Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models. Oncotarget. 2015 Jul 30; 6(21): 18545-18557. Published online 2015 May 19. Doi:10.18632/oncotarget.4186. PMCID: PMC4621909
  • Joshua Hempstead, Dustin P. Jones, Abdelali Ziouche, Gwendolyn M. Cramer, Imran Rizvi, Stephen Arnason, Tayyaba Hasan, Jonathan P. Celli Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models. Sci Rep. 2015; 5: 10093.  Published online 2015 May 12. doi: 10.1038/srep10093. PMCID: PMC4428052
  • Srivalleesha Mallidi, Bryan Q. Spring, Tayyaba Hasan. Optical Imaging, Photodynamic Therapy and Optically-Triggered Combination Treatments. Cancer J. 2015 May-Jun; 21(3): 194–205. doi: 10.1097/PPO.0000000000000117. PMCID: PMC4459538
  • Jonathan T. Elliott, Kimberley S. Samkoe, Jason R. Gunn, B.S., Errol E. Stewart, Timothy B. Gardner, Kenneth M. Tichauer, Ting-Yim Lee, P. Jack Hoopes, D. V. M., Stephen P. Pereira, Tayyaba Hasan, and Brian W. Pogue. Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study. Acad Radiol. 2015 May;22(5):572-9. PMID: 25683500
  • Srivalleesha Mallidi, Zhiming Mai, Imran Rizvi, Joshua Hempstead, Stephen Arnason, Jonathan Celli, Tayyaba Hasan. In vivo evaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints. J Biomed Opt. 2015 Apr; 20(4): 048003.  Published online 2015 Apr 24. doi: 10.1117/1.JBO.20.4.048003. PMCID: PMC4408448
  • Bryan Q. Spring, Imran Rizvi, Nan Xu, Tayyaba Hasan. The role of photodynamic therapy in overcoming cancer drug resistance. Photochem Photobiol Sci. 2015 Aug; 14(8): 1476–1491. Published online 2015 Apr 9.  doi: 10.1039/c4pp00495g. PMCID: PMC4520758
  • Jonathan T. Elliott, Kimberley S. Samkoe, Jason R. Gunn, Errol E. Stewart, Timothy B. Gardner, Kenneth M. Tichauer, Ting-Yim Lee, P. Jack Hoopes, Stephen P. Pereira, Tayyaba Hasan, Brian W. Pogue. Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreas cancer model: a pilot study. Acad Radiol. Acad Radiol. 2015 May; 22(5): 572–579. Published online 2015 Feb 14.  doi: 10.1016/j.acra.2014.12.014. PMCID: PMC4395543
  • Kishore R Rollakanti, Sanjay Anand, Edward V Maytin. Vitamin D enhances the efficacy of photodynamic therapy in a murine model of breast cancer. Cancer Med. 2015 May; 4(5): 633–642.  Published online 2015 Feb 25. doi: 10.1002/cam4.361. PMCID: PMC4430256
  • Srivalleesha Mallidi, Kohei Watanabe, Dmitriy Timerman, David Schoenfeld, Tayyaba Hasan. Prediction of Tumor Recurrence and Therapy Monitoring Using Ultrasound-Guided Photoacoustic Imaging. Theranostics. 2015; 5(3): 289–301. Published online 2015 Jan 1. doi: 10.7150/thno.10155. PMCID: PMC4279192


  • Kimberley S. Samkoe, Kenneth M. Tichauer, Jason R. Gunn, Wendy A. Wells, Tayyaba Hasan, Brian W. Pogue. Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach. Cancer Res. 2014 Dec 15; 74(24): 7465–7474. Published online 2014 Oct 24.  doi: 10.1158/0008-5472.CAN-14-0141. PMCID: PMC4268352
  • M G Keane, L Horsfall, G Rait, S P Pereira. A case-control study comparing the incidence of early symptoms in pancreatic and biliary tract cancer. BMJ Open. 2014; 4(11): e005720.  Published online 2014 Nov 19. doi:10.1136/bmjopen-2014-005720. PMCID: PMC4244441
  • Sanjay Anand, John Ebner, Christine B. Warren, Manu S. Raam, Melissa Piliang, Steven D. Billings, Edward V. Maytin. C/EBP Transcription Factors in Human Squamous Cell Carcinoma: Selective Changes in Expression of Isoforms Correlate with the Neoplastic State. PLoS One. 2014; 9(11): e112073.  Published online 2014 Nov 17. doi:10.1371/journal.pone.0112073. PMCID: PMC4234316
  • Matthew T. Huggett, E.L. Culver, M. Kumar, J.M. Hurst, M. Rodriguez-Justo, M.H. Chapman, G.J. Johnson, S.P. Pereira, R.W. Chapman, George J.M. Webster, E. Barnes. Type 1 Autoimmune Pancreatitis and IgG4-Related Sclerosing Cholangitis Is Associated With Extrapancreatic Organ Failure, Malignancy, and Mortality in a Prospective UK Cohort. Am J Gastroenterol. Am J Gastroenterol. 2014 Oct; 109(10): 1675-1683. Published online 2014 Aug 26. doi:10.1038/ajg.2014.223. PMCID: PMC4552254
  • Stephen Chad Kanick, Scott C. Davis, Yan Zhao, Tayyaba Hasan, Edward V. Maytin, Brian W. Pogue, M. Shane Chapman. Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis. J Biomed Opt. 2014 Jul; 19(7): 075002.  Published online 2014 Jul 4. doi: 10.1117/1.JBO.19.7.075002. PMCID: PMC4082494
  • Darragh P. O‚ÄôBrien, Neomal S. Sandanayake, Claire Jenkinson, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Evangelia-Ourania Fourkala, Stephane Camuzeaux, Oleg Blyuss, Richard Gunu, Anne Dawnay, Alexey Zaikin, Ross C. Smith, Ian J. Jacobs, Usha Menon, Eithne Costello, Stephen P. Pereira, John F. Timms. Serum CA19-9 is significantly up-regulated up to 2 years prior to diagnosis with pancreatic cancer: implications for early disease detection. Clin Cancer Res. 2015 Feb 1; 21(3): 622-631. Published online 2014 Jun 17.doi:10.1158/1078-0432.CCR-14-0365. PMCID: PMC4181906
  • Bryan Q. Spring, Akilan Palanisami, Tayyaba Hasan. Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy. J Biomed Opt. 2014 Jun; 19(6): 066006.  Published online 2014 Jun 11. doi: 10.1117/1.JBO.19.6.066006. PMCID: PMC4053439
  • Sanjay Anand, Kishore R. Rollakanti, Ronald L. Horst, Tayyaba Hasan, Edward V. Maytin. Combination of Oral Vitamin D3 with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma. Photochem Photobiol. 2014 Sep; 90(5): 1126–1135. Published online 2014 May 26.  doi: 10.1111/php.12286. PMCID: PMC4186664
  • Michael Jermyn, Scott C. Davis, Hamid Dehghani, Matthew T. Huggett, Tayyaba Hasan, Stephen P. Pereira, Stephen G. Bown, Brian W. Pogue. CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy.. Phys Med Biol. 2014 Apr 21; 59(8): 1911–1921. Published online 2014 Mar 20.  doi: 10.1088/0031-9155/59/8/1911. PMCID: PMC4229843
  • Margaret G Keane, Konstantinos Bramis, Stephen P Pereira, Giuseppe K Fusai. Systematic review of novel ablative methods in locally advanced pancreatic cancer. World J Gastroenterol. 2014 Mar 7; 20(9): 2267-2278. Published online 2014 Mar 7. doi:10.3748/wjg.v20.i9.2267. PMCID: PMC3942832
  • Nazanin Hamzei, Kimberley S Samkoe, Jonathan T Elliott, Robert W Holt, Jason R Gunn, Tayyaba Hasan, Brian W Pogue, Kenneth M Tichauer. Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors. Austin J Biomed Eng. Author manuscript; available in PMC 2014 Nov 18. Published in final edited form as: Austin J Biomed Eng. 2014 Mar 5; 1(1). PMCID: PMC4235770
  • Bryan Q. Spring, Adnan O. Abu-Yousif, Akilan Palanisami, Imran Rizvi, Xiang Zheng, Zhiming Mai, Sriram Anbil, R. Bryan Sears, Lawrence B. Mensah, Ruth Goldschmidt, S. Sibel Erdem, Esther Oliva, Tayyaba Hasan. Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10): E933–E942.  Published online 2014 Feb 26. doi: 10.1073/pnas.1319493111. PMCID: PMC3956156
  • M T Huggett, M Jermyn, A Gillams, R Illing, S Mosse, M Novelli, E Kent, S G Bown, T Hasan, B W Pogue, S P Pereira. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer. Br J Cancer. 2014 Apr 1; 110(7): 1698-1704. Published online 2014 Feb 25. doi:10.1038/bjc.2014.95. PMCID: PMC3974098
  • Yuan Chen, Lakshmana Ayaru, Sanju Mathew, Emma Morris, Stephen P. Pereira, Shahriar Behboudi. Expansion of Anti-Mesothelin Specific CD4+ and CD8+ T Cell Responses in Patients with Pancreatic Carcinoma. PLoS One. 2014; 9(2): e88133.  Published online 2014 Feb 10. doi:10.1371/journal.pone.0088133. PMCID: PMC3919833
  • Srivalleesha Mallidi, Sriram Anbil, Seonkyung Lee, Dieter Manstein, Stefan Elrington, Garuna Kositratna, David Schoenfeld, Brian Pogue, Steven J. Davis, Tayyaba Hasan. Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema. J Biomed Opt. 2014 Feb; 19(2): 028001.  Published online 2014 Feb 6. doi: 10.1117/1.JBO.19.2.028001. PMCID: PMC3915169
  • Jonathan P. Celli, Imran Rizvi, Adam R. Blanden, Iqbal Massodi, Michael D. Glidden, Brian W. Pogue, Tayyaba Hasan. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Sci Rep. 2014; 4: 3751.  Published online 2014 Jan 17. doi: 10.1038/srep03751. PMCID: PMC3894557